- Title
- No evidence for association between rs10191329 severity locus and longitudinal disease severity in 1813 relapse-onset multiple sclerosis patients from the MSBase registry
- Creator
- Campagna, Maria Pia; Havrdova, Eva Kubala; van der Walt, Anneke; Butzkueven, Helmut; Jokubaitis, Vilija G.; Horakova, Dana; Izquierdo, Guillermo; Matesanz, Fuencisla; Eichau, Sara; Lechner-Scott, Jeanette; Taylor, Bruce Multiple sclerosis, disease severity, genetics.; Garcia-Sanchez, Maria-Isabel; Alcina, Antonio
- Relation
- Multiple Sclerosis Journal Vol. 30, Issue 9, p. 1216-1220
- Publisher Link
- http://dx.doi.org/10.1177/13524585241240406
- Publisher
- Sage
- Resource Type
- journal article
- Date
- 2024
- Description
- Background: The International Multiple Sclerosis Genetics Consortium and MultipleMS Consortium recently reported a genetic variant associated with multiple sclerosis (MS) severity. However, it remains unclear if these variants remain associated with more robust, longitudinal measures of disease severity. Methods: We examined the top variant, rs10191329, from Harroud et al.’s study in 1813 relapse-onset MS patients from the MSBase Registry to assess association with longitudinal disease severity. Results: Our analysis revealed no significant association between rs10191329 genotype and longitudinal binary disease severity (p > 0.05). Conclusion: These findings highlight the complexity of genetic factors mediating long-term MS outcomes and the need for further research.
- Subject
- multiple sclerosis; disease severity; genetics; registries
- Identifier
- http://hdl.handle.net/1959.13/1511806
- Identifier
- uon:56556
- Identifier
- ISSN:1352-4585
- Rights
- © The Author(s), 2024. This article is distributed under the terms of the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/) which permits any use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
- Language
- eng
- Full Text
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